Director of Discovery ADME Services Q Squared Solutions Indianapolis, Indiana
Sponsored By:
Description: High resolution accurate mass (HRAM) systems typically detect little alterations in the masses of compounds that lower resolution detection may miss. In this presentation, we will talk about role of HRAM in detection of molecules in understanding molecular pathology of disease (biomarker), etiology, patient (Biomarker) stratification based on physiologic, transcriptomic, proteomic and metabolic footprints, alone or in parallel. We will touch upon practical examples of oligonucleotides and Proteins/Peptide.
Learning Objectives:
What is role of Liquid-chromatography, high-resolution, accurate mass spectrometry (HRAM LC-MS) in qualitative & quantitative clinical and pre-clinical analysis of small endogenous molecules, biomarkers, oligonucleotides and proteins.
How is HRAM LC-MS is getting leveraged in confident peak assignment and to get elemental composition of an ion that is not available with lower resolution detection.
What is the role of High-resolution accurate-mass (HRAM) MS fin metabolomic profiling with precise quantitation and strong performance repeatability from sample to sample and run to runs.
