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Advances in Discovery, Formulation, and Delivery of New Modalities
Prologue

Prologue: Opportunities and Challenges for Lipid-Based Drug Delivery Systems for Biopharmaceuticals

PRE-RECORDED
Location:Online Only

Advances

Non-viral lipid based drug delivery are showing great promise as gene medicines of the future. COVID-19 mRNA vaccines developed by BioNtech/Pfizer and Moderna are spectacular examples of how in rapid fashion, millions of doses were manufactured for world-wide vaccination campaigns. Now there are over 250 clinical trials ongoing using such non-viral gene medicine modalities for indications in rare diseases, inherited diseases, chronic diseases, and cancer. These medicines offer advantages such as cost of goods, rapid deployment and manufacture, low cost, and accessibility to the patient population.

The presentation covers topics of what an acceptable drug delivery system should look like, differences between liposomes and lipid nanoparticles. And in what modalities they should be used. Finally the future opportunities and challenges of these new modalities are discussed.

Learning Objectives:

  • Upon completion, participant will be able to understand different drug delivery systems for biologics.
  • Upon completion, participant will be able to discuss requirements for a pharmaceutically-acceptable drug delivery system.
  • Upon completion, participant will be able to evaluate the advantages and limitations of different drug delivery options for biologics and how to develop a DDS for their specific application.
  • Upon completion, participant will be able to understand the basic differences between liposomes and lipid nanoparticles in terms of their characteristics and applications in biotechnology.