Novel Engineering and Formulation Based Approaches for Delivery of CART to Solid Tumors

Title: Novel Engineering and Formulation Based Approaches for Delivery of CART to Solid Tumors

Abstract:

The delivery of Chimeric Antigen Receptor T-cell (CART) therapy holds immense promise for the treatment of solid tumors. However, achieving effective delivery to solid tumors remains a significant challenge. This presentation explores novel engineering and formulation-based approaches aimed at enhancing the delivery of CART therapy to solid tumors.

We will discuss innovative strategies for engineering CART cells with enhanced tumor-homing capabilities, including the use of targeting ligands and genetic modifications. Additionally, we will delve into advanced formulation techniques such as nanoparticle-based delivery systems and hydrogels designed to improve the retention and penetration of CART cells within the tumor microenvironment.

Furthermore, we will highlight recent advancements in the development of biomaterials and scaffolds that facilitate the localized delivery of CART cells to solid tumors, minimizing off-target effects and enhancing therapeutic efficacy.

Overall, this presentation provides insights into cutting-edge approaches that harness engineering and formulation principles to overcome barriers associated with CART therapy delivery in solid tumors, paving the way for improved outcomes and expanded therapeutic applications in oncology.

Session: Symposium: Drug Delivery for New Modalities and Therapies