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A
T1030-02-06
A Mechanistic Model of IgG4-RD Identifies High-Potential Therapy Targets
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T1130-02-10
A Novel Approach to Mechanical Characterization of Pharmaceutical Lyospheres
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T1430-02-10
A Novel In Vitro Serum Stability Assay for Antibody Therapeutics Incorporating Internal Standards
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T1230-02-07
A Validated Immunocapture LC-MS/MS Hybrid Assay for the Quantitation of a Novel Multi-Domain Therapeutic Protein in Human Plasma with Clinical Sample Analysis
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W1530-02-06
Age-Dependent Reduction in Hepatic Vector Genome Loss in Juvenile OTC
spf-ash
Mice Following a Single Dose of DTX301 and Partial Compensation Achieved with a Higher Dose
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W1530-02-10
An “I” (Immunogenicity Risk Assessment) for an Eye (Ophthalmology Biologics)
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W1430-02-10
Analysis of Anti-Drug Antibodies (ADA) in Multiple Animal Species from mRNA LNP Therapeutics Supporting Rare Diseases Demonstrated Low Immunogenicity of PEG-2000 by ECLA and ELISA Methodology
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T1430-02-07
Analysis of Glucagon-Like Peptide-1 (GLP-1) Analog in Rat Plasma Using an LC-MS/MS Workflow
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T1030-02-07
Analytical Method Validation Strategy for Determination of Charge Heterogeneity of Antibody Therapeutics Using Reference Material Comparison as an Alternative to Spiking Studies
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W1030-02-06
Antibody Synthesis in Cell-Free for High-Throughput Production and Screening
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T1130-02-07
Anti-CCR8 Mediated Depletion of Tumor-Infiltrating Regulatory T Cells: Preclinical PK/PD and Translational Strategy in Support of Clinical Development for Solid Tumor Indications
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W1430-02-06
Application of a Novel Affinity Purified Chicken IgY in an Immunoaffinity LC-MS/MS Assay for Rapid Quantitation of Monoclonal Antibody Therapeutics and ADCs in Nonclinical Species
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B
T1130-02-06
Biodistribution Analysis of GPC-3 CAR-T Cells in NSG Mice by a Universal ddPCR Assay to Support an IND-Enabling Toxicity Study
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W1130-02-07
Biodistribution Study of a Bivalent SARS-CoV-2 mRNA Vaccine in Rat
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T1430-02-09
Bridging Bevacizumab PK from Adults to Pediatrics through PBPK Modeling
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C
W1430-01-05
Characterization of Protein Antigens in Liposomal Vaccines Using Differential Scanning Fluorimetry
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W1130-02-10
Choosing the Right Bioanalytical Platform to Accommodate a Biotherapeutic Pharmacokinetic Measurement in Serum and CSF: A Case Study
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W1030-02-07
Comparative Analyses of Thermal Stability Amplifying Peptide Dendrons and Polysorbates
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W1130-02-11
Comparison of a Microfluidic Generic Total Antibody (TAb) Assay with Independent Neutralizing Antibody (NAb) and TAb Assays for the Detection of Pre-existing Antibodies against AAV Vectors
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W1230-02-11
Comprehensive Assessment of Immunogenicity Risk of Host Cell Proteins in Biologics and Vaccines Using In Silico and In Vitro Methods
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T1530-02-08
Cross Validation of Pharmacokinetic Assays: Experimental and Statistical Design
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D
W1330-01-03
Deciphering the Role of Hydrogel Network Topology in Programmably Degradable Hydrogels
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W1030-02-10
Delivery of Carbonic Anhydrase 9 siRNA by Lipid Nanoparticles
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T1030-01-02
Demonstrating the Excipient Effect In Vitro for Pre-clinical Formulation Analysis
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W1030-02-09
Design and Evaluation of a Cyclic Peptide-Epirubicin Conjugate to Enhance Anticancer Activity and Reduce Cardiac Toxicity
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T1530-02-10
Development of a Generic, Automated, Microfluidic Human IgG-FcRn Affinity Assay In-Solution for Use in Antibody Engineering
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T1230-02-10
Development of a Highly Sensitive Immunoassay to Measure Circulating Levels of a Nanobody-Based Imaging Agent
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W1230-01-05
Development of a Marburg Self-amplifying mRNA-Lipid Nanoparticle Vaccine: Differential Effects When Co-formulated with Toll Receptor Agonists
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T1530-02-06
Development of an Electrochemiluminescent Assay for the Detection of Anti-PEG IgE Antibodies in Human Serum
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T1230-01-05
Development of Inhalable Polymeric Nanoemulsions for Delivery of Gene Silencing Therapeutics in Lung Tumors
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W1530-02-09
Development of Non-Cell Based Potency Assays for Bispecific Antibodies
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T1030-01-01
Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides
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T1330-01-01
Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides II Circular Dichroism Spectroscopy and Nuclear Magnetic Resonance Analysis for Determining Higher-Order Structure
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W1030-01-01
Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides III Thermodynamic Analysis on Higher-Order Structure of Oligonucleotides
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W1230-01-01
Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides IV Evaluation of Compactness of Oligonucleotides for Determining Their Higher-Order Structure
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W1430-01-01
Development of Physicochemical Profiling Platform for Therapeutic Oligonucleotides V Biological Function Analysis of Oligodeoxynucleotides
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W1230-02-07
Docetaxel and QDs Based Nano Lipidic Theragnostic System for Cure and Real-Time Monitoring of Breast Cancer: Efficacy and Safety Studies in Rats
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E
W1230-01-03
Elastin-Like Polypeptide (ELP) Antibody Fusions Targeting IL-6: Pharmacology and Pharmacokinetics
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T1430-01-02
Enhanced Transdermal Delivery of Anticancer Agent: A Comprehensive Study on Fractional Ablative Laser
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W1330-02-07
Enhancing Antibody Detection for PABAD-Based Neutralizing Antibody Detection and Validation
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T1030-02-09
Evaluating the Effects of Differently Charged Linker-Drugs on Pharmacokinetics and Tissue Distribution of Antibody Drug Conjugates
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W1530-02-11
Evaluation of API 7500 Integrated System with Microflow LC System M5 Using Sulfamethazine (SDX) Neat Solution
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T1130-02-09
Evaluation of Sample Preparation Techniques for Protein Quantification
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W1430-02-09
Exploring the Future Potentials of High-Resolution Mass Spectrometry for Regulated Bioanalysis
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W1330-01-05
Extrapolating the Use of Microfluidic Chips to Formulate Reproducible and Effective Nanoemulsions for Subunit Vaccines: A Paradigm Shift in Manufacturing Emulsion Adjuvants
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F
T1530-02-09
False Positive or Not? – Assessing Potential Interference of Soluble Target to ADA Detection for a Clinical Stage Program
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T1030-01-05
Flash Nanoprecipitation Permits Self-assembly of Ionizable Lipid Nanoparticles for Nucleic Acid Delivery
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T1330-01-02
Formulation Development and Characterization of a Marburg Self-amplifying mRNA-Lipid Nanoparticle Vaccine with a Toll-Like Receptor 7 Agonist
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T1530-02-11
Formulation Development and Characterization of a Marburg Self-amplifying mRNA-Lipid Nanoparticle Vaccine with CpG Oligonucleotide
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G
T1330-02-09
Gyrolab Generic Anti-drug Antibody Assay Streamlines Preclinical Immunogenicity Assessment
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H
W1430-01-02
High Concentration Protein Suspensions: A Case Study for Subcutaneous Delivery of Bevacizumab
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I
W1130-02-09
Immunogenicity Risk Assessment of Salmon Calcitonin Peptide Impurities Using In Silico and In Vitro Methods
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W1230-01-02
Impact of Amino Acids as Excipients in Biologic Drug Products Formulation Development
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W1430-02-08
In Vitro Method Using Circulating Tumor Cells-Derived Organoids from Patients with Solid Tumors to Transform Oncology Drug Development
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W1430-01-04
Innovative Device for Concomitant Therapeutic Compound Delivery into the Brain and Neural Recordings - Feasibility Bench and In Vivo Studies
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T1530-02-07
Integrated HypoSkin® Model and PBPK Modeling as a Bioavailability Predicting Tool for Subcutaneous Delivery of Protein Therapeutics
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T1230-02-06
Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Overview
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T1430-02-06
Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Post-Translational Modification (1) C-terminal Lys Clipping
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W1330-02-06
Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Post-Translational Modification (1) Deamidation
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W1130-02-06
Interlaboratory Study of Multi-Attribute Method (MAM) for Antibody Therapeutics – Post-Translational Modification (2) Oxidation
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T1130-02-08
Intestinal Organoid as a Predictive Model for the Assessment of Nano-Drug Delivery Systems
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T1430-01-04
Ionizable Lipid Nanoparticles for Dual siRNA/Chemotherapy Delivery for B-cell ALL Treatment
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T1230-01-04
Iontophoretic Transdermal Delivery of a Bioactive Molecule: Comparison of Nanoliposomal Platforms with Passive Delivery
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L
W1230-02-09
LC-MS FFPE Tissue Analysis Across Multiple Murine Tissues Supports Mouse Relevance for On-Target/Off-Tumor Toxicity Assessment for Anti-STEAP2 CAR-T Therapeutic Development
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T1430-02-08
Leveraging Buprenorphine as a Tool Molecule to Develop a Novel PBPK Model Accounting for Intestinal Lymphatic Absorption
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M
W1030-02-11
Machine Learning Approaches to Analysis of Microscopy Images of Polysorbate Degradation Product Particles
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N
W1330-02-10
Next-Generation Biocompatible HPLC System for Enhanced Analysis of Biotherapeutics
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W1530-02-08
Non-invasive Molecular Imaging of V3 Receptors to Localize ACTH-Dependent Cushing's Syndrome and Precision Surgery of Corticotropinoma
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T1330-02-10
Novel Immunoassay Technology: Evaluating the PIXI Platform for Rapid Quantitation with Automation, Wide Dynamic Range, and Small Sample Volume Requirement
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W1430-02-07
Novel Use of Recombinant Dimeric IgA Monoclonal Antibodies as Cyst-Targeted Therapeutics in Polycystic Kidney Disease
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O
T1330-02-11
Oligonucleotide Dual Hybridization Assay Using Offline Pre-incubation followed by an Automated Microfluidic Method
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W1330-02-11
One Drop of Blood, Multiple Sets of Data --- Establishing A Common Protocol for Serotype Specific IGG Concentration Testing Using Mitra® VAMS Dry Blood Samples to Support Vaccine Clinical Studies
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W1030-02-08
Optimization of Artificial Colonic Mucus for Drug Diffusion Study
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T1330-02-07
Optimizing and Validating an In Vitro Transcytosis Assay for Predicting Pharmacokinetics in Drug Discovery and Process Development
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T1330-01-05
Optimizing Lipid Nanoparticles (LNPs) Processing for siRNA Delivery by Microfluidics System
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W1130-02-08
Oral Absorption of Semaglutide: Pharmacokinetic Modeling and Molecular Dynamics Simulations
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W1030-01-03
Oral Delivery of Remdesivir Analogues: Alternatives for Intravenous Remdesivir with Reduced Potential Drug-Drug Interactions
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P
T1230-01-01
Parallel-Competitive Absorption Metabolism Model for Calculation of Subcutaneous Bioavailability of Monoclonal Antibodies
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W1330-01-02
Poloxamer 188 and Propylene Glycol Loaded with Novel Pyridine-Based 1,2,4-Triazolo-Tethered Indole Conjugate as Rectal Suppository to Treat Colorectal Cancer
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T1230-02-09
Population Pharmacokinetics and Exposure-Efficacy and -Safety Analyses of Atezolizumab for Subcutaneous Injection in Patients with Locally Advanced or Metastatic Non-small Cell Lung Cancer
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W1030-01-02
Potential Biomedical Applications of Silver Nanoparticles Synthesized Using Anisotes trisulcus Extract from Saudi Arabia: Antioxidant, Antibacterial, and Anti-Proliferative Properties
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T1330-01-04
Predicting the Aggregation Behavior of Liposomes Using Thermal Analysis
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W1030-01-04
Preparation and Scale-Up of Liposomal Amphotericin B Formulation and a Comparison with Commercially Available Counterpart, Ambisome®
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T1330-02-08
Production and Characterization of Critical Biotin and DIG Conjugated RESCA-Anti-CD8 VHH Reagents to Enable the Non-Clinical and Clinical Anti-Drug Antibody Assay Development
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W1330-01-04
Prolonged Ocular Delivery of Sunitinib from Poly (diol-tricarballylate) Injectable Biodegradable Elastomeric Tiny Implant for Diabetic Retinopathy Treatment
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Q
W1230-02-10
Qualification of a 48-plex Cytokine Olink Panel to Support Rare Disease and Pediatric Clinical Studies
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T1230-02-08
Quantitation of Soluble Tumor-Associated Antigens (sTAA) in Tumor Interstitial Fluid (TIF) Isolated from Frozen Solid Tumors
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R
T1130-02-11
Rapid and Predictive Immunogenicity Risk Assessments Using In Silico Methods
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S
T1230-02-11
Sensitive Quantitation of Antisense Oligonucleotides Using Capitainer
®
qDBS Microsampling Device Coupled with Hybridization LC-MS/MS
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T1030-02-08
Single Cell Gel Electrophoresis to Detect Genotoxicity of Iminostilbene, a Process Induced Impurity of Carbamazepine
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T1030-01-03
Stability of Therapeutic Monoclonal Antibodies during Infusion with Elastomeric Pumps Intended for Home-Based Therapy
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W1330-01-01
Stabilization of Viruses for Vaccines and Gene Therapy by Spray Drying and Lyophilization
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T1330-01-03
Stain-Free Approach to Determine and Monitor Cell Heath Using Supervised and Unsupervised Image-Based Deep Learning
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T1430-01-01
Static Light Scattering Signatures Used to Identify and Minimize Aggregation During Formulation Development
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W1230-02-06
Strategies for the Development and Characterization of Sensitive Anti-oligonucleotide Antibodies for Application in Anti-drug Antibody Assays
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T1030-02-10
Synthesis a Cationic-Polymer Incorporating Carboxylesterase Active Ester for the Delivery of CRISPR/Cas9 to Ameliorate Hyperlipidemia
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T
T1030-02-11
The Importance of Orthogonal Methods for the Determination of the Size Distribution of Lipid Nanoparticles
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U
W1330-02-09
Using Cryo-TEM to Characterize Structural Details of LNPs during Manufacturing
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T1330-02-06
Utilizing a Bead-Based Sample Pretreatment to Overcome Drug Interference in Developing a Ligand Binding Neutralizing Antibody Assay
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V
T1430-01-03
Val-His-Ser (VHS) N-terminal Leader Sequence and Implications for mAb Subcutaneous Pharmacokinetics
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